Article

Mechanistic Deconvolution of Tuberculosis Treatment Failure: A Multi-Omic and Causal Network Approach

2026-01-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The global tuberculosis (TB) epidemic is increasingly characterized by 'recycled' cases—patients who fail treatment or relapse, fueling transmission and drug resistance. Current diagnostic tools are inadequate for predicting these unfavorable outcomes at the point of care. While blood transcriptomic signatures have been developed, they typically lack mechanis...

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Literature Corpus work: 0b18bfbc-7069-57da-a788-261aada972c2
DOI: 10.21203/rs.3.rs-8512316/v1

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