Article

Detection of PCR chimeras in adaptive immune receptor repertoire sequencing using hidden Markov models

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) has emerged as a central approach for studying T cell and B cell receptor populations, and is now an important component of studies of autoimmunity, immune responses to pathogens, vaccines, allergens, and cancers, and for antibody discovery. When amplifying the rearranged V(D)J genes encoding antigen receptors, each cycle of the Polymeras...

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Literature Corpus work: 0ae33a8e-415d-502f-9959-4ff59e656fce
DOI: 10.1101/2025.02.21.638809

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