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Article

SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements

9 Feb 2010

Abstract excerpt

MOTIVATION: The inference of pre-mutation immunoglobulin (Ig) rearrangements is essential in the study of the antibody repertoires produced in response to infection, in B-cell neoplasms and in autoimmune disease. Often, there are several rearrangements that are nearly equivalent as candidates for a given Ig gene, but have different consequences in an analysis. Our aim in this article is to develop a probabilistic...

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PMID: 20147303
DOI: 10.1093/bioinformatics/btq056

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