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Article

{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia.

The Journal of physiology - 1 Apr 2009

Lee Urvi S, Cui Jianmin

Abstract excerpt

Large conductance Ca(2+)-activated K(+) (BK) channels modulate many physiological processes including neuronal excitability, synaptic transmission and regulation of myogenic tone. A gain-of-function (E/D) mutation in the pore-forming alpha subunit (Slo1) of the BK channel was recently identified and is linked to human neurological diseases of coexistent generalized epilepsy and paroxysmal dyskinesia. Here we...

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Identifiers

PMID: 19204046
DOI: 10.1113/jphysiol.2009.169243
PMCID: PMC2678220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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