Article
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia.
The Journal of physiology - 1 Apr 2009
Lee Urvi S, Cui Jianmin
Abstract excerpt
Large conductance Ca(2+)-activated K(+) (BK) channels modulate many physiological processes including neuronal excitability, synaptic transmission and regulation of myogenic tone. A gain-of-function (E/D) mutation in the pore-forming alpha subunit (Slo1) of the BK channel was recently identified and is linked to human neurological diseases of coexistent generalized epilepsy and paroxysmal dyskinesia. Here we...
Topics
- Animals
- Binding Sites
- Calcium
- Chorea
- Epilepsy
- Female
- Gene Transfer Techniques
- Humans
- Ion Channel Gating
- Kinetics
- Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
- Large-Conductance Calcium-Activated Potassium Channel beta Subunits
- Membrane Potentials
- Microinjections