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Article

A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.

Biophysical journal - 1 May 2008

Guo Zhaohua, Lv Caixia, Yi Hong, Xiong Yu, Wu Yingliang, Li Wenxin, Xu Tao, Ding Jiuping

Abstract excerpt

Single large-conductance calcium-activated K(+) (BK) channels encoded by the mSlo gene usually have synchronous gating, but a Drosophila dSlo (A2/C2/E2/G5/10) splice variant (dSlo1A) exhibits very flickery openings. To probe this difference in gating, we constructed a mutant I323T. This channel exhibits four subconductance levels similar to those of dSlo1A. Rectification of the single-channel current-voltage...

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Identifiers

PMID: 18400952
DOI: 10.1529/biophysj.107.120022
PMCID: PMC2292367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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