Article

Single-Cell Multi-Modal Differential Analysis of the Human Neo-Cortex in HIV Infection Reveals Similarities with Hallmarks of Alzheimer’s Disease

2025-11-01

Abstract excerpt

<title>Abstract</title> <p>Cognitive impairment in people with HIV (PWH) remains prevalent despite viral suppression. To provide insights into the cellular mechanisms of pathogenesis, we carried out a multi-modal pan cell-type specific differential analysis of the frontal cortex of PWH. We show cell type-specific dysregulations of oxidative phosphorylation, glycolysis, ribosomes and translation, DNA damage, and n...

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Literature Corpus work: 8b8f7695-cdb2-56c0-aea9-321150e8034e
DOI: 10.21203/rs.3.rs-7636879/v1

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Single-Cell Multi-Modal Differential Analysis of the Human Neo-Cortex in HIV Infection Reveals Similarities with Hallmarks of Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-7636879/v1Read

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