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Article

Elucidating the structural basis of Fgd1-mediated resistance to Delamanid in Mycobacterium tuberculosis.

Journal of molecular graphics & modelling - 1 Jul 2026

Saxena Shalini, Guruprasad Lalitha

Abstract excerpt

Delamanid and Pretomanid are nitro-dihydro-imidazooxazole derivatives essential for the treatment of multidrug-resistant tuberculosis (MDR-TB). The emergence of tuberculosis resistance to Delamanid necessitates understanding the molecular mechanisms underlying this resistance. This study focuses on the structural analysis of the fgd1 protein in both wild-type and mutant forms to explain the molecular basis of...

Topics

Oxazoles
Mycobacterium tuberculosis
Molecular Dynamics Simulation
Nitroimidazoles
Mutation
Drug Resistance, Bacterial
Bacterial Proteins
Guanine Nucleotide Exchange Factors
Quantum Mechanics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41911659
DOI: 10.1016/j.jmgm.2026.109382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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