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Article

Elucidating the structural basis of Fgd1-mediated resistance to Delamanid in Mycobacterium tuberculosis.

Journal of molecular graphics & modelling - 1 Jul 2026

Saxena Shalini, Guruprasad Lalitha

Abstract excerpt

Delamanid and Pretomanid are nitro-dihydro-imidazooxazole derivatives essential for the treatment of multidrug-resistant tuberculosis (MDR-TB). The emergence of tuberculosis resistance to Delamanid necessitates understanding the molecular mechanisms underlying this resistance. This study focuses on the structural analysis of the fgd1 protein in both wild-type and mutant forms to explain the molecular basis of...

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Identifiers

PMID: 41911659
DOI: 10.1016/j.jmgm.2026.109382

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