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Article

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Science (New York, N.Y.) - 1 Jan 2016

Saxton Robert A, Knockenhauer Kevin E, Wolfson Rachel L, Chantranupong Lynne, Pacold Michael E, Wang Tim, Schwartz Thomas U, Sabatini David M

Abstract excerpt

Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine sensor. Here we present the 2.7 angstrom crystal structure of Sestrin2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26586190
DOI: 10.1126/science.aad2087
PMCID: PMC4698039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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