Article

MEK1/2 Inhibitors Induce Class 1 Alcoholic Dehydrogenase (ADH1) Expression by Regulating Farnesoid X Receptor

2021-10-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Alcohol is mainly catabolized by class 1 alcohol dehydrogenase (ADH1) in liver. ADH deficiency can aggravate ethanol-induced tissue injury. Extracellular signal-regulated kinases 1/2 (ERK1/2) is involved in alcohol metabolism. However, the relationship between ERK1/2 and ADH1 remains unclear. <bold>Methods and Results</bold>: To inhibit ERK1/2, HepG2 and BNL cel...

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Literature Corpus work: a96adc95-aa9e-5166-8af1-0265c9485bd8
DOI: 10.21203/rs.3.rs-981887/v1

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