Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease

Abstract excerpt

<title>Abstract</title> <p>Alcohol use disorder is a widespread illness commonly leading to alcoholic liver disease (ALD) and cirrhosis with an increased incidence of hepatocellular carcinoma (HCC), but the mechanisms of alcohol-related oncogenesis in the liver are incompletely understood. We tested the hypothesis that ALD predisposes to HCC via dysregulation of splicing. RNA sequencing was performed on liver bio...

Topics

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• Alcohol Consumption and Health Effects
• Diet, Metabolism, and Disease
• Epigenetics and DNA Methylation
• Genomics, phytochemicals, and oxidative stress
• Lipid metabolism and biosynthesis
• Liver Disease Diagnosis and Treatment
• RNA modifications and cancer
• RNA Research and Splicing

Identifiers and source

Literature Corpus work

3e1d370b-437c-511a-aa5d-df58a2182cc1

DOI

10.21203/rs.3.rs-7380649/v1