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Article

Atomistic ensemble of active SHP2 phosphatase.

Communications biology - 21 Dec 2023

Anselmi Massimiliano, Hub Jochen S

Abstract excerpt

SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental disorders and are linked to hematological malignancies and cancer. SHP2 comprises two tandemly-arranged SH2 domains, a catalytic PTP domain, and a disordered C-terminal tail. Under physiological, non-stimulating conditions, the catalytic site of PTP is occluded by the...

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PMID: 38129686
DOI: 10.1038/s42003-023-05682-5
PMCID: PMC10739809

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