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Article

Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer.

Journal of the National Cancer Institute - 1 Aug 2024

Sun Jing, Zhao Jianhui, Zhou Siyun, Li Xinxuan, Li Tengfei, Wang Lijuan, Yuan Shuai, Chen Dong, Law Philip J, Larsson Susanna C, Farrington Susan M, Houlston Richard S, Dunlop Malcolm G, Theodoratou Evropi, Li Xue

Abstract excerpt

BACKGROUND: We aimed to identify plasma and urinary metabolites related to colorectal cancer (CRC) risk and elucidate their mediator role in the associations between modifiable risk factors and CRC. METHODS: Metabolite quantitative trait loci were derived from 2 published metabolomics genome-wide association studies, and summary-level data were extracted for 651 plasma metabolites and 208 urinary metabolites....

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PMID: 38648753
DOI: 10.1093/jnci/djae089
PMCID: PMC11308169

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