Article

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib leads to Potent and Selective Quinoline-based HIPK4 Inhibitor AZ137

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by pharmacological inhibition remains to be determined. However, such investigations have been hampered by a lack of high-quality ch...

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Literature Corpus work: 0a8d74ca-3412-5cc4-a7ae-c5e73cf8c6fa
DOI: 10.64898/2026.04.22.720179

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