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Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer

17 Feb 2020

Abstract excerpt

Kinases are signalling proteins which have proven to be successful targets for the treatment of a variety of diseases, predominantly in cancers. However, only a small proportion of kinases (<20%) have been investigated for their therapeutic viability, likely due to the lack of available chemical tools across the kinome. In this work we describe initial efforts in the development of a selective chemical tool for...

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PMID: 32085971
DOI: 10.1016/j.bmcl.2020.127040

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