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Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

16 Nov 2021

Abstract excerpt

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). HIPKs are regulators of various signaling pathways and involved in the pathology of cancer, chronic fibrosis, diabetes, and multiple neurodegenerative diseases. Here, we report the crystal structure of HIPK3 in its apo form at 2.5 Å...

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PMID: 34785661
DOI: 10.1038/s41467-021-26935-z

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