Article

Decoupling nucleolar stress from DNA-damage in HCT116 colon cancer cells by targeting the interaction between ribosomal assembly factors Bop1/WDR12

2026-03-13

Abstract excerpt

<h4>ABSTRACT</h4> Ribosome biogenesis is a hallmark of cancer and has emerged as an effective target for treatment. This study investigates novel strategies in cancer therapy by disrupting specific protein-protein interactions essential for the ribosome biogenesis process. Using peptide mimetics derived from human Bop1, conjugated with cell-penetrating sequences, we assessed their binding affinity, cellular inter...

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Literature Corpus work: 0a84bf51-89b5-50ab-ab7a-ec54cad8b0db
DOI: 10.64898/2026.03.11.711022

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Decoupling nucleolar stress from DNA-damage in HCT116 colon cancer cells by targeting the interaction between ribosomal assembly factors Bop1/WDR12DOI 10.64898/2026.03.11.711022Read

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