Article

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

2023-07-29

Abstract excerpt

<h4>Summary</h4> The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the "WIN" site that tethers WDR5 to chromatin. WIN site inhibitors (WINi) are active against multiple cancer cell types in vitro, the most notable of which are those derived from MLL-rearranged (MLLr) leukemias. Pep...

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Literature Corpus work: ed6ef331-e29a-570d-adea-87f7c0edd791
DOI: 10.1101/2023.07.26.550648

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