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Article

Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.

Molecular pharmaceutics - 5 Jan 2015

Peterson Erica J, Menon Vijay R, Gatti Laura, Kipping Ralph, Dewasinghe Dilhara, Perego Paola, Povirk Lawrence F, Farrell Nicholas P

Abstract excerpt

TriplatinNC is a highly positively charged, substitution-inert derivative of the phase II clinical anticancer drug, BBR3464. Such substitution-inert complexes form a distinct subset of polynuclear platinum complexes (PPCs) interacting with DNA and other biomolecules through noncovalent interactions. Rapid cellular entry is facilitated via interaction with cell surface glycosoaminoglycans and is a mechanism unique...

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Identifiers

PMID: 25407898
DOI: 10.1021/mp5006867
PMCID: PMC4334294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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