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Targeting Ribosome Biogenesis for Cancer Therapy with Oral Platinum Complexes

17 Dec 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Cancer cells often upregulate ribosome biogenesis to meet increased protein synthesis demands for rapid proliferation; therefore, targeting ribosome biogenesis has emerged as a promising cancer therapeutic strategy. Herein, we introduce two Pt complexes, ataluren monosubstituted platinum(IV) (SPA, formula: c,c,t,-[Pt(NH 3 ) 2 Cl 2 (OH)(C 15 H 8 FN 2 O 3 )], where...

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PMID: 39886599
DOI: 10.1021/jacsau.4c00652

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