Article

Using a simple cellular assay to map NES motifs in cancer-related proteins, gain insight into CRM1-mediated NES export, and search for NES-harbouring micropeptides

2020-08-04

Abstract excerpt

<h4>ABSTRACT</h4> The nuclear export receptor CRM1 (XPO1) recognizes and binds specific sequence motifs termed nuclear export signals (NESs) in cargo proteins. About 200 NES motifs have been identified, but over a thousand human proteins are potential CRM1 cargos, and most of their NESs remain to be identified. On the other hand, the interaction of NES peptides with the “NES-binding groove” of CRM1 has been studi...

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Literature Corpus work: 0a83cdfc-a50e-599c-b043-17904a49750a
DOI: 10.1101/2020.08.04.234948

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