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Article

PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis.

The Journal of biological chemistry - 1 May 2026

Jurynec Michael J, Nosyreva Elena, Thompson David, Novak Kendra A, Matheson Derek J, Veerabhadraiah Shivakumar R, Ma Ying, Smith Matthew C, Kazmers Nikolas H, Feier Stefan, Ullah Ghanim, Syeda Ruhma

Abstract excerpt

Synovial joints respond to physical forces to maintain tissue homeostasis. Disruption of joint homeostasis results in the development of osteoarthritis (OA), a disease characterized by abnormal remodeling of joint tissues. PIEZO1 is a mechanosensitive cation channel in the joint directly regulated by mechanical stimulus. To test whether PIEZO1 is associated with OA susceptibility, we determined whether variants...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41935834
DOI: 10.1016/j.jbc.2026.111426
PMCID: PMC13157073

Genes

PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis.PMID 41935834Read ↗

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