Article

PIEZO1-mediated mechanosensation links aging to bladder dysfunction

2026-05-25

Abstract excerpt

<h4>SUMMARY</h4> Aging is accompanied by profound changes in bladder function, leading to increased urinary frequency and incontinence that impair quality of life in humans and are recapitulated in mouse models. Bladder filling and emptying rely on precise mechanosensory feedback, yet how aging alters this sensory control remains unclear. PIEZO ion channels convert mechanical forces into cellular signals essentia...

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Literature Corpus work: 751d8156-0df0-5d34-a56f-a4c6faaad8a2
DOI: 10.64898/2026.05.24.726025

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