Article

Genetic variation at IL7 provides mechanistic insights into toxicity to immune checkpoint blockade

2022-04-12

Abstract excerpt

<title>Abstract</title> <p>Although treatment with immune checkpoint blockade (ICB) has transformed outcomes for patients with melanoma (1, 2), it frequently triggers immune related adverse events (irAEs), causing serious morbidity and presenting a major hurdle to immuno-oncology (3, 4). The degree to which germline genetic variation predisposes to irAEs is unknown. Here, studying a cohort of 214 patients receivi...

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Literature Corpus work: 0a6f27db-1db1-52d5-9182-53aebc8ccf47
DOI: 10.21203/rs.3.rs-1531341/v1

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