Article
Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma.
The Journal of investigative dermatology - 1 Sept 2004
Allen Matthew, Pratscher Barbara, Roka Florian, Krepler Clemens, Wacheck Volker, Schöfer Christian, Pehamberger Hubert, Müller Markus, Lucas Trevor
Abstract excerpt
Expression of melanoma differentiation associated gene-7 (mda-7) also known as interleukin 24 (IL-24) decreases during melanoma cell differentiation and induces apoptosis in melanoma cells but not in melanocytes. Here we identify a novel splice variant of the cancer growth suppressor gene mda-7/IL-24 (mda-7s) that is differentially expressed in RNA preparations from normal human melanocytes, transformed...
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