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Predicting immune-related adverse events in patients with melanoma: the role of interleukin-7 rs16906115 polymorphism and lymphocyte dynamics

26 Jun 2025

Abstract excerpt

Introduction: Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of malignant melanoma; however, they are frequently associated with immune-related adverse events (irAEs). Emerging evidence suggests that genetic predispositions, including interleukin-7 (IL-7) gene variants, may influence the risk of these toxicities. Methods: In this single-center retrospective study, we investigated...

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PMID: 40642097
DOI: 10.3389/fimmu.2025.1616325

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