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Article

Association between PD-1 single nucleotide gene variants and the risk of metastatic melanoma.

Archives of dermatological research - 16 Jun 2024

Boutros Andrea, Carosio Roberta, Campanella Dalila, Banelli Barbara, Morabito Anna, Pistillo Maria Pia, Croce Elena, Queirolo Paola, Tanda Enrica Teresa, Raposio Edoardo, Fontana Vincenzo, Spagnolo Francesco

Abstract excerpt

Previous studies showed an association between single nucleotide gene variants (SNVs) of PD-1 and cancer susceptibility. We analyzed PD1.5 C > T and PD1.7 T > C SNVs to investigate their association with the risk of developing metastatic melanoma (MM). Utilizing a cohort of 125 MM patients treated with anti-PD-1 agents and 84 healthy controls, we examined genotype/allele frequencies through a modified Poisson...

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Identifiers

PMID: 38880834
DOI: 10.1007/s00403-024-03034-9
PMCID: PMC11180627

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