Article

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

2019-05-09

Abstract excerpt

The AGER gene encodes for a number of RAGE isoforms, with the membrane bound signal transduction and “decoy” circulating soluble RAGE being the best characterised. Here we demonstrate a novel nuclear isoform of RAGE in mice and human kidney cortex which by cell and size fractionation we determined to be approximately 37kda. This nuclear RAGE isoform is functional and binds to DNA sequences within the upstream 5’...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a529bdc-24b8-502e-aab9-f4d5c2441d42
DOI: 10.1101/632596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal TissueDOI 10.1101/632596Read

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and DiseaseSemantic proximity Read

Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene.Semantic proximity Read

-374 T/A RAGE polymorphism is associated with chronic kidney disease progression in subjects affected by nephrocardiovascular disease.Semantic proximity Read

Identification, classification, and expression of RAGE gene splice variants.Semantic proximity Read

Alternative splicing of the murine receptor for advanced glycation end‐products (RAGE) geneSemantic proximity Read

Association of the receptor for advanced glycation end products (RAGE) -374 T/A gene polymorphism and circulating soluble RAGE with nephropathy in type 1 diabetic patients.Semantic proximity Read

Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injurySemantic proximity Read

Receptor for age (RAGE) is a gene within the major histocompatibility class III region: implications for host response mechanisms in homeostasis and chronic diseaseSemantic proximity Read

RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts.Semantic proximity Read

Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race.Semantic proximity Read

-374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension.Semantic proximity Read

Endogenous secretory receptor for advanced glycation end-products and cardiovascular disease in end-stage renal disease.Semantic proximity Read