Article
-374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2013
Kawai Tatsuo, Kamide Kei, Ito Norihisa, Onishi Miyuki, Oguro Ryosuke, Takeya Yasushi, Tatara Yuji, Maekawa Yoshihiro, Katsuya Tomohiro, Ohishi Mitsuru, Rakugi Hiromi
Abstract excerpt
Receptor of advanced glycation end products (RAGE) is reportedly linked with chronic inflammatory diseases due to aging or diabetes. The aim of this study was to show how -374 T/A RAGE has an impact on systemic vascular damage and renal function. The study subjects were a total of 468 essential hypertension patients from the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study cohort. We...
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