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Article

-374 T/A RAGE polymorphism is associated with chronic kidney disease progression in subjects affected by nephrocardiovascular disease.

PloS one - 1 Jan 2013

Baragetti Ivano, Norata Giuseppe Danilo, Sarcina Cristina, Baragetti Andrea, Rastelli Francesco, Buzzi Laura, Grigore Liliana, Garlaschelli Katia, Pozzi Claudio, Catapano Alberico Luigi

Abstract excerpt

BACKGROUND: Chronic kidney disease (CKD) patients present elevated advanced glycation end products (AGEs) blood levels. AGEs promote inflammation through binding to their receptor (RAGE), located on the membrane of mesangial cells, endothelial cells and macrophages. Several genetic polymorphisms influence RAGE transcription, expression and activity, including the substitution of a thymine with an adenine (T/A) in...

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Identifiers

PMID: 23593165
DOI: 10.1371/journal.pone.0060089
PMCID: PMC3617170

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