Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Abstract excerpt

WD40 repeat-containing protein 91 regulates endosomal phosphatidylinositol 3-phosphate levels at the critical stage of endosome maturation and plays vital roles in endosome fusion, recycling, and transport by mediating protein-protein interactions. Due to its various roles in endocytic pathways, WDR91 has recently been identified as a potential host factor responsible for viral infection. We employed DNA-Encoded C...

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• Chemical Synthesis and Analysis
• Monoclonal and Polyclonal Antibodies Research
• Neuroblastoma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• RNA and protein synthesis mechanisms
• Signaling Pathways in Disease
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

0a4dbd74-8995-51a5-a21e-b710e8797da7

DOI

10.1101/2023.08.21.552681