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Article

Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction

3 Jan 2023

Abstract excerpt

WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such as cancer, aging, and neurodegenerative disorders. Interactions between WDR5 and various partners are essential for sustaining its function. Most drug discovery efforts center on the WIN (WDR5 interaction motif) site...

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PMID: 36594833
DOI: 10.1021/acschembio.2c00843

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