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Epigenetic g predicts cognitive aging and incident dementia in a diverse, nationally representative sample of older adults

2025-12-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Alzheimer’s disease and related dementias (ADRD) are major public health concerns. DNA methylation (DNAm)–based biomarkers such as GrimAge and PhenoAge predict aging and health risk, but were not designed to optimize prediction of cognitive decline. Epigenetic g —a DNAm-derived index of general cognitive ability—is a promising marker of cognitive function that has not been...

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Literature Corpus work
0a470d3b-fab4-53ed-9cc2-8ce5e8e49c5d
DOI
10.64898/2025.12.23.25342931
Open publication

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Epigenetic g predicts cognitive aging and incident dementia in a diverse, nationally representative sample of older adultsDOI 10.64898/2025.12.23.25342931
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