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MethylCog predicts six-year cognitive ability beyond blood-based ADRD biomarkers

2026-05-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> MethylCog is a 29-CpG blood DNA methylation (DNAm) proxy for general cognitive ability (g). Its incremental association with blood biomarkers of Alzheimer’s disease and related dementias (ADRD) and prospective cognitive ability remains unclear. <h4>METHODS</h4> In the held-out test set from the original MethylCog study, we tested whether MethylCog explained baseline g be...

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Literature Corpus work
98531ee9-a7f2-52be-884b-393650d11b59
DOI
10.64898/2026.05.26.26354133
Open publication

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MethylCog predicts six-year cognitive ability beyond blood-based ADRD biomarkersDOI 10.64898/2026.05.26.26354133
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