Article
Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2013
Micel Lindsey N, Tentler John J, Smith Peter G, Eckhardt Gail S
Abstract excerpt
The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a sequential series of enzymatic processes using four key enzyme families: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-carrier proteins), E3 (ubiquitin-protein ligases), and E4 (ubiquitin chain assembly factors). Because the UPS...
Topics
- Antineoplastic Agents
- Cell Transformation, Neoplastic
- Cyclin-Dependent Kinase Inhibitor p27
- DNA-Binding Proteins
- Humans
- Male
- Mutation
- Oncogene Proteins, Viral
- Prostatic Neoplasms
- Proteasome Endopeptidase Complex