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E3 Ubiquitin Ligases as Cancer Targets and Biomarkers

1 Aug 2006

Abstract excerpt

E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins. Together with ubiquitin-activating enzyme E1 and ubiquitin-conjugating enzyme E2, E3 ubiquitin ligases catalyze the ubiquitination of a variety of biologically significant protein substrates for targeted degradation through the 26S proteasome, as well as for nonproteolytic...

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PMID: 16925947
DOI: 10.1593/neo.06376

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