Article

Inhibitory effect of eslicarbazepine acetate and S-licarbazepine on Na <sub>v</sub> 1.5 channels

2020-04-25

Abstract excerpt

Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95 % of circulating active metabolites. S-Lic is the main enantiomer responsible for anticonvulsant activity and this is proposed to be through the blockade of voltage-gated Na + channels (VGSCs). ES...

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Literature Corpus work: 0a3f0736-c1f4-512c-9a23-b5f3fa00fe63
DOI: 10.1101/2020.04.24.059188

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