Article
Voltage-gated sodium channels in epilepsy.
Epilepsia - 1 Nov 2002
Köhling Rüdiger
Abstract excerpt
Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage-gated sodium channels. This review summarizes recent data on changes of sodium channel expression, molecular structure and function associated...
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