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The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers.

Journal of neurochemistry - 1 Jul 2020

Toffoli Marco, Smith Laura, Schapira Anthony H V

Abstract excerpt

The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well-studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the...

Topics

Genetic Predisposition to Disease
Glucosylceramidase
Heterozygote
Humans
Mutation
Parkinson Disease
Protein Structure, Quaternary
alpha-Synuclein

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31965564
DOI: 10.1111/jnc.14968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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