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Article

MUSE-XAE: MUtational Signature Extraction with eXplainable AutoEncoder enhances tumour types classification.

Bioinformatics (Oxford, England) - 2 May 2024

Pancotti Corrado, Rollo Cesare, Codicè Francesco, Birolo Giovanni, Fariselli Piero, Sanavia Tiziana

Abstract excerpt

MOTIVATION: Mutational signatures are a critical component in deciphering the genetic alterations that underlie cancer development and have become a valuable resource to understand the genomic changes during tumorigenesis. Therefore, it is essential to employ precise and accurate methods for their extraction to ensure that the underlying patterns are reliably identified and can be effectively utilized in new...

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PMID: 38754097
DOI: 10.1093/bioinformatics/btae320
PMCID: PMC11139523

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