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Article

Signature-aware deep learning reveals distinct driver gene programs and mutational processes in glioblastoma and colon adenocarcinoma.

Computational biology and chemistry - 1 Aug 2026

Zubair Muhammad, Li Jianqiang, Qian Jun

Abstract excerpt

The precise identification of cancer driver mutations is essential for precision oncology; however, it remains a significant challenge because of the overwhelming presence of passenger mutations and the complexity of mutational processes. In this study, we introduce ResMLP-GL, a signature-aware residual multilayer perceptron designed for variant-level cancer driver prediction, which explicitly integrates COSMIC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41764951
DOI: 10.1016/j.compbiolchem.2026.108984

Genes

APC
EGFR
KRAS
PIK3CA
POLE
PTEN
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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