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Single-cell transcriptomics of blood identified IFIT1 neutrophil subcluster expansion in NTM-PD patients

19 Jun 2024

Abstract excerpt

• This is the first study to perform transcriptome analysis in NTM-PD patients at single-cell resolution. • The results provide a useful framework for studying the role of cell subclusters in NTM disease progression. • Specific expansion of IFIT1 + neutrophil subcluster and the CXCL8-CXCR1/2 axis may be involved in the pathogenesis of NTM-PD. Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is caused by...

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PMID: 38901242
DOI: 10.1016/j.intimp.2024.112412

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