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Article

Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.

BMC biochemistry - 10 Sept 2008

Mayorov Vladimir I, Lowrey Angela J, Biousse Valerie, Newman Nancy J, Cline Susan D, Brown Michael D

Abstract excerpt

BACKGROUND: Autosomal dominant optic atrophy (ADOA), a form of progressive bilateral blindness due to loss of retinal ganglion cells and optic nerve deterioration, arises predominantly from mutations in the nuclear gene for the mitochondrial GTPase, OPA1. OPA1 localizes to mitochondrial cristae in the inner membrane where electron transport chain complexes are enriched. While OPA1 has been characterized for its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18783614
DOI: 10.1186/1471-2091-9-22
PMCID: PMC2547100

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.PMID 18783614Read ↗

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