A novel platform for metabolomics using barcoded structure-switching aptamers

Abstract excerpt

Small organic molecules like metabolites and drugs are critical for diagnostics, treatment, and synthetic biology. Measuring them presents two key challenges however: they are biochemically highly diverse and there is no method to amplify them. Mass spectrometry has been the workhorse of metabolomics for decades but is costly and slow and single-cell metabolomics remains very challenging. Here we describe an alter...

Topics

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• Aptamers, Nucleotide
• COVID-19
• Fluorescent Dyes
• Nucleic Acid Amplification Techniques
• Point Mutation
• Polymorphism, Single Nucleotide
• RNA, Viral
• SARS-CoV-2

Identifiers and source

Literature Corpus work

094c0877-40fc-5617-a471-6aa1377e23e3

DOI

10.1101/2023.06.09.544402