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Article

In vitro selection of an allosteric ribozyme that transduces analytes to amplicons.

Nature biotechnology - 1 Jan 1999

Robertson M P, Ellington A D

Abstract excerpt

We have selected an allosteric ribozyme ligase from a random sequence population that is activated up to 10,000-fold by oligonucleotide effectors. The ribozyme conforms to a classic two-state model for allostery in which the equilibrium between inactive and active conformers is dramatically altered by the presence of effector ligands. In the presence of the effector the allosteric ribozyme ligase generates...

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Identifiers

PMID: 9920271
DOI: 10.1038/5236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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