Article

Functional brain age prediction suggests accelerated aging in preclinical familial Alzheimer’s disease, irrespective of fibrillar amyloid-beta pathology

2020-05-08

Abstract excerpt

We aimed at developing a model able to predict brain aging from resting state functional connectivity (rs-fMRI) and assessing whether genetic risk/determinants of Alzheimer’s disease (AD) and amyloid (Aβ) pathology contributes to accelerated brain aging. Using data collected in 1340 cognitively unimpaired participants from 18 to 94 years old selected across multi-site cohorts, we showed that chronological age can...

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Literature Corpus work: 0930a0ee-ca11-5cf4-80fe-394244a9f10d
DOI: 10.1101/2020.05.06.076745

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