Article

Oolonghomobisflavans from <i>Camellia sinensis</i> disaggregate tau fibrils across Alzheimer’s disease models

2024-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a common debilitating neurodegenerative disease with limited treatment options. Amyloid-β (Aβ) and tau fibrils are well-established hallmarks of AD, which can induce oxidative stress, neuronal cell death, and are linked to disease pathology. Here, we describe the effects of Oolonghomobisflavan A (OFA) and Oolonghomobisflavan B (OFB) on tau fibril disaggregation and pr...

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Literature Corpus work: 54757131-3214-5702-bf04-be385ab7dd57
DOI: 10.1101/2024.02.26.582120

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