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L-Carnitine protects against methotrexate-induced hepatotoxicity via regulation of apoptosis and metabolic pathways

2025-09-16

Abstract excerpt

<title>Abstract</title> <p>Background Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive drug; however, its clinical application is limited by dose-dependent hepatotoxicity mediated by oxidative stress, mitochondrial dysfunction, and apoptosis. Objective This study aimed to evaluate the hepatoprotective potential of L-carnitine (LCR), a mitochondrial cofactor with antioxidant and anti-apop...

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Literature Corpus work
090d34d7-7812-590e-93ff-a0bbb423d310
DOI
10.21203/rs.3.rs-7429081/v1
Open publication

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L-Carnitine protects against methotrexate-induced hepatotoxicity via regulation of apoptosis and metabolic pathwaysDOI 10.21203/rs.3.rs-7429081/v1
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