Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2010

Gane Edward J, Weilert Frank, Orr David W, Keogh Geraldine F, Gibson Michael, Lockhart Michelle M, Frampton Christopher M, Taylor Kenneth M, Smith Robin A J, Murphy Michael P

Abstract excerpt

BACKGROUND: Increased oxidative stress and subsequent mitochondrial damage are important pathways for liver damage in chronic hepatitis C virus (HCV) infection; consequently, therapies that decrease mitochondrial oxidative damage may improve outcome. The mitochondria-targeted anti-oxidant mitoquinone combines a potent anti-oxidant with a lipophilic cation that causes it to accumulate several-hundred fold within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Alanine Transaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartate Aminotransferases

Share to Double-Blind Method

Share to Interferons

Share to Mitochondria, Liver

Share to Organophosphorus Compounds

Share to Ubiquinone

Source

Identifiers

PMID: 20492507
DOI: 10.1111/j.1478-3231.2010.02250.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients.PMID 20492507Read ↗

Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.Semantic proximity Read ↗

Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical modelsSemantic proximity Read ↗

HCV and Oxidative Stress in the LiverSemantic proximity Read ↗

Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings.Semantic proximity Read ↗

Longitudinal effects of hepatitis C virus treatment on hepatic mitochondrial dysfunction assessed by C-methionine breath test.Semantic proximity Read ↗

Mitochondrial DNA copy number in Hepatitis C virus-related chronic liver disease: impact of direct-acting antiviral therapySemantic proximity Read ↗

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.Semantic proximity Read ↗

L-Carnitine protects against methotrexate-induced hepatotoxicity via regulation of apoptosis and metabolic pathwaysSemantic proximity Read ↗

Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats.Semantic proximity Read ↗

Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagySemantic proximity Read ↗

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C VirusSemantic proximity Read ↗

Impact of amino acid substitutions in hepatitis C virus core region on the severe oxidative stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.