Article

Oral pre-treatment with Citronellol ameliorates Methotrexate-induced nephrotoxicity in Wistar rats via targeting oxidative stress and inflammation

2024-10-07

Abstract excerpt

<h4>Background: </h4> Methotrexate (MTX) is a classical folic acid antagonist widely used in the treatment of malignant and non-malignant disorders. However, its clinical application is often restricted by concomitant adverse effects, including renal damage. Numerous studies have highlighted the role of oxidative stress and inflammation in mediating MTX-related nephrotoxicity. Therefore, the current study aimed to...

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Literature Corpus work: 91c01ef9-c5e3-56bd-8db5-52e4ad0fca9a
DOI: 10.12688/f1000research.156625.1

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