Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The vulnerabilities of chemotherapy resistant pancreatic cancer revealed by organoids of pre- and post-neoadjuvant therapy.

Cancer letters - 31 Mar 2026

Wang Huan, Li Yunguang, Tang Shijie, Li Yikai, Zhang Yehan, Yin Xiaoyi, He Juan, Zhu Yiqin, Zhang Yi, Shi Xiaohan, Sun Maoyuan, Gao Suizhi, Li Bo, Zhu Lingyu, Yuan Shuai, Pan Yaqi, Shi Meilong, Li Penghao, Teng Chuanqi, Zhong Chaoliang, Yang Xiaolu, Fu Zhendong, Liu Xinyu, Kang Xiaochao, Kang Yining, Li Wenjie, Zheng Kailian, Song Bin, Jing Wei, Xu Xiongfei, Guo Shiwei, Chen Luonan, Gao Dong, Jin Gang

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to intrinsic and acquired chemotherapy resistance, particularly after neoadjuvant therapy (NAT). To uncover therapy-induced vulnerabilities, we established matched patient-derived organoids from PDAC tissues obtained before and after NAT, creating a unique platform to track treatment-driven evolution. Comparative analysis of these organoids...

Topics

Join the communities discussing this publication.

Albumins
Carcinoma, Pancreatic Ductal
Deoxycytidine
Gemcitabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoadjuvant Therapy

Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 41565051
DOI: 10.1016/j.canlet.2026.218252

Genes

KRAS
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The vulnerabilities of chemotherapy resistant pancreatic cancer revealed by organoids of pre- and post-neoadjuvant therapy.PMID 41565051Read ↗

Patient-derived organoids guide personalized therapy for KRAS-mutant pancreatic cancer: synergistic MEK/mTOR inhibition and predictive chemotherapy responses.Semantic proximity Read ↗

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatmentSemantic proximity Read ↗

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoidsSemantic proximity Read ↗

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity Read ↗

Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug RepurposingSemantic proximity Read ↗

Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancerSemantic proximity Read ↗

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic CancerSemantic proximity Read ↗

Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma TumorsSemantic proximity Read ↗

Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer.Semantic proximity Read ↗

Ecoevolutionary biology of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data.Semantic proximity Read ↗

Pancreatic cancer organoids derived from EUS-guided fine needle aspiration specimens can be used to predict chemotherapy resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.